Report || Late breaker 2 – Further highlights

Late-breaking session 2 is available to view on demand – watch the presentations now.

Light exposure and atherosclerosis

Alternate cycles of light and dark, but not continuous light, directly aggravates atherosclerosis development in an experimental model. Researchers from Leiden University Medical Center, the Netherlands, suggest that this is most likely mediated via increased migration of monocytes into the atherosclerotic plaque.

Schilperoort M, et al. Alternating light-dark cycles, but not continuous light, aggravates atherosclerosis development in APOE*3-Leiden.CETP mice 

Long non-coding RNAs

According to this study from the Brigham and Women’s Hospital, Boston, USA, long non-coding RNAs may have a role in regulating DNA damage repair in the vessel wall, with potential implications for chronic vascular disease states, such as atherosclerosis.

Feinberg MW. LncRNA-mediated control of vascular senescence and atherosclerosis

Angiogenic barrier integrity

The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier. The ERAD-associated ubiquitin ligase MARCH6 appears to be a determinant of angiogenic barrier integrity, via controlling cellular cholesterol homeostasis according to this report from Amsterdam University Medical Center, the Netherlands.

Tan JME. The MARCH6-SQLE Axis controls endothelial cholesterol homeostasis and angiogenic sprouting.

LDL receptor regulation

This study involving a consortium of investigators from around Europe, identified a novel complex, the U2-spliceosome and its interactors, involved in the post-transcriptional regulation of LDL receptor activity in humans.

Zanoni P, et al. The U2-spliceosome and its interactors regulate the levels and activity of the LDL receptor in humans.